Can a Multi-Epitope Vaccine be a solution for COVID-19 pandemic?

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2, the causative agent of coronavirus disease (COVID-19)) has caused relatively high mortality rates in humans throughout world since its first detection late December 2019, leading to most devastating pandemic current century. Consequently, SARS-CoV-2 therapeutic interventions have received priority from public health authorities. Despite increased COVID-19 infections, a vaccine or therapy cover all population is not yet available. Herein, immunoinformatics and custommune tools were used identify B T-cells epitopes available sequences spike (S) protein. In silico predictions, six cell QTGKIADYNYK, TEIYQASTPCNGVEG, LQSYGFQPT, IRGDEVRQIAPGQTGKIADYNYKLPD, FSQILPDPSKPSKRS PFAMQMAYRFNG cross-reacted with MHC-I MHC-II binding selected for vaccination experimental animals evaluation as candidate vaccine(s) due thei...